The mechanism of therapeutic action of local negative pressure (LNP) performed on the AndroSPOK magnetophotobarotherapy apparatus.

The principle of action is based on the creation of a local negative pressure in a mini-pressure chamber with a penis placed in it by evacuating air from the chamber.

The exhaustion created with the hand pump in the vacuum flask of the AndroSPOK magnetophotobarotherapy apparatus by three to four pump strokes is not less than 10 kPa (≈ 0.1 atm).

The effect of LNP-therapy on the cavernous bodies of the penis is associated with a sharp increase in penile blood flow by reducing the external pressure on the penile vessels. This leads to the dilation of penile vessels and the opening of a large number of previously non-functioning capillaries. Local increase in blood flow in the penis leads to the maximum filling of cavernous bodies with blood. In addition, an effective stimulation of the baro-, thermo-, and chemoreceptors of the penis usually takes place. Activation of these receptors triggers a number of specific sexual reactions associated with penile erection.

The effect of LNP on the penis is accompanied by active oxygenation and hyperemia of the penile tissues. The oxygen saturation of blood in the lungs occurs in normal conditions (under normal atmospheric pressure), whereas exchange in penile tissues occurs at a pressure much lower than atmospheric pressure (due to a local negative pressure that is less than 150-300 mm Hg). This causes a more intensive diffusion of oxygen from the blood into tissues, which are under conditions of negative pressure. Due to the difference in pressures and, consequently, the increased blood flow to the organ, most of the smallest capillaries are opened and active.

Temperature is an essential factor. The lower the body temperature, the more oxygen binds to hemoglobin and, conversely, when the temperature increases, the affinity of hemoglobin and oxygen decreases dramatically. In this case oxygen binding in the patient’s lungs occurs at relatively lower temperatures, and the penis warms up during the procedure, which also contributes to tissue oxygenation.

The effects of LNP are also associated with a powerful effect on peripheral blood and lymph circulation in all this area.  This increases the metabolism, mobilizes the central and peripheral mechanisms of blood circulation, and improves tissue trophism. Increased metabolism in the penile tissues contributes to the neutralization of degenerative changes in cavernous bodies.  These facts provide opportapparatusies for the use of LNP-therapy in the complex treatment of Peyronie disease. In addition, the increased blood flow during the LNP-therapy session can reduce congestion in the pelvic region, which is very important in the treatment of congestive disorders (for example, in chronic prostatitis).




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